Pei-Hsuan Chen Selected Research

1- (2,4- dichlorophenyl)- N- (piperidin- 1- yl)- 4- ((pyrrolidine- 1- sulfonamido)methyl)- 5- (5- ((4- (trifluoromethyl)phenyl)ethynyl)thiophene- 2- yl)- 1H- pyrazole- 3- carboxamide

12/2013

Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice.

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Pei-Hsuan Chen Research Topics

Disease

15	Neoplasms (Cancer) 01/2023 - 12/2008
6	Burns 10/2014 - 05/2007
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2019 - 12/2015
4	Insulin Resistance 01/2022 - 01/2020
4	Inflammation (Inflammations) 01/2022 - 01/2020
4	Infections 01/2019 - 01/2013
4	Sepsis (Septicemia) 05/2014 - 04/2010
3	Pneumonia (Pneumonitis) 01/2019 - 07/2011
2	Lymphoma (Lymphomas) 01/2023 - 01/2020
2	Atherosclerosis 01/2023 - 01/2018
2	Glucose Intolerance 01/2022 - 02/2016
2	Obesity 01/2020 - 07/2012
2	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020 - 12/2019
2	Carcinogenesis 11/2018 - 11/2011
2	Dysbiosis 01/2018 - 01/2016
2	Adenocarcinoma 01/2016 - 12/2008
1	Metabolic Diseases (Metabolic Disease) 01/2023
1	Type 2 Diabetes Mellitus (MODY) 01/2021
1	Non-alcoholic Fatty Liver Disease 04/2020
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2020
1	Acute Liver Failure (Fulminant Hepatic Failure) 01/2020
1	Cytokine Release Syndrome 01/2020
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2020
1	Melanoma (Melanoma, Malignant) 01/2020
1	Necrosis 01/2020
1	Microsatellite Instability 12/2019
1	Hodgkin Disease (Hodgkin's Disease) 12/2019
1	Disease Progression 12/2019
1	Granuloma 09/2019
1	Cysts 09/2019
1	Bacterial Infections (Bacterial Infection) 01/2019
1	Adenocarcinoma of Lung 01/2019
1	Lung Neoplasms (Lung Cancer) 11/2018
1	Healthcare-Associated Pneumonia 01/2018
1	Diabetic Nephropathies (Diabetic Nephropathy) 02/2016
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2016
1	Hyperglycemia 01/2016
1	Purpura 10/2014

Drug/Important Bio-Agent (IBA)

7	Anti-Bacterial Agents (Antibiotics)IBA 01/2019 - 06/2010
6	LigandsIBA 01/2020 - 11/2008
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 12/2008
5	CytokinesIBA 01/2022 - 01/2013
3	Insulin (Novolin)FDA Link 01/2022 - 12/2008
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2016
3	LipidsIBA 04/2020 - 11/2011
3	DNA (Deoxyribonucleic Acid)IBA 07/2013 - 12/2009
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2013 - 11/2008
3	Toll-Like Receptors (Toll-Like Receptor)IBA 07/2011 - 11/2008
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2023 - 01/2017
2	Glucose (Dextrose)FDA LinkGeneric 04/2020 - 11/2011
2	axicabtagene ciloleucelIBA 01/2020 - 01/2020
2	dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA 01/2020 - 01/2018
2	CarbonIBA 12/2019 - 11/2011
2	AntibodiesIBA 09/2019 - 08/2014
2	Peroxynitrous Acid (Peroxynitrite)IBA 01/2019 - 04/2010
2	Glutamine (L-Glutamine)FDA Link 01/2019 - 11/2011
2	Phosphotransferases (Kinase)IBA 01/2018 - 04/2010
2	Serine (L-Serine)FDA Link 04/2016 - 12/2015
2	Peroxidase (Myeloperoxidase)IBA 07/2013 - 04/2010
2	pyrazolanthroneIBA 04/2010 - 05/2007
2	NF-kappa B (NF-kB)IBA 12/2009 - 12/2008
1	AdiponectinIBA 01/2023
1	Interleukin-10 (Interleukin 10)IBA 01/2022
1	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 01/2021
1	OligosaccharidesIBA 01/2020
1	Volatile Fatty AcidsIBA 01/2020
1	Bile Acids and Salts (Bile Acids)IBA 01/2020
1	OxygenasesIBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	Cell Adhesion MoleculesIBA 01/2020
1	Tryptophan (L-Tryptophan)FDA Link 01/2020
1	Analgesics (Analgesic Drugs)IBA 01/2020
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2020
1	Double-Stranded RNA (RNA, Double Stranded)IBA 01/2020
1	4,6-dinitro-o-cresol (DNOC)IBA 01/2020
1	indole-3-carbinolIBA 01/2020
1	Messenger RNA (mRNA)IBA 12/2019
1	Programmed Cell Death 1 ReceptorIBA 12/2019
1	ApolipoproteinsIBA 12/2019
1	Peptides (Polypeptides)IBA 12/2019
1	pembrolizumabIBA 12/2019
1	GlutaminaseIBA 01/2019
1	Lactic Acid (Lactate)FDA LinkGeneric 11/2018
1	EnzymesIBA 11/2018
1	Peptide Hydrolases (Proteases)FDA Link 11/2018
1	Basigin (Extracellular Matrix Metalloproteinase Inducer (EMMPRIN))IBA 11/2018
1	trimethyloxamine (trimethylamine N-oxide)IBA 01/2018
1	PrebioticsIBA 01/2018
1	Tigecycline (Tygacil)FDA Link 01/2017
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 02/2016
1	Streptozocin (Streptozotocin)FDA Link 02/2016
1	Blood Glucose (Blood Sugar)IBA 02/2016
1	EndotoxinsIBA 01/2016
1	Ligases (Synthetase)IBA 01/2016
1	N-acetylaspartate (N-acetyl aspartate)IBA 01/2016
1	DefensinsIBA 01/2016
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 12/2015

Therapy/Procedure

6	Therapeutics 01/2023 - 01/2013
2	Immunotherapy 01/2021 - 01/2020
1	Drug Therapy (Chemotherapy) 01/2020